Application Research of Different Compression Model on Four Powder Excipients Compression / 中国药学杂志

OBJECTIVE: To conduct the contrastive studies of universal compression model to pharmaceutical powder compression characteristics effect base on Heckel and Kawakita equation founded.METHODS: The uniaxial compression tests were developed with three excipients of lactose, starch, microcrystalline cellulose and four mixture excipients of lactose, starch, microcrystalline cellulose with different mass fraction. The change rules between density and pressure and model error are analyzed of two different compression models respectively.RESULTS: The absolute density error value of Heckel and Kawakita compression model is within 4%, when the pressure is greater than 80 MPa,and the variance of Kawakita model is less than Heckel model.The absolute error value of Heckel and Kawakita compression model is within 3.73%, when the pressure is larger than 60 MPa, and the variance of Kawakita compression model less than Heckel model.CONCLUSION: During applying two universal compression models to analyze pharmaceutical powder compression characteristics, two models are suitable, when the pressure is between 80 and 240 MPa.

Theoretical modeling and experimental research on direct compaction characteristics of multi-component pharmaceutical powders based on the Kawakita equation / 药学学报

Base on the Kawakita powder compression equation, a general theoretical model for predicting the compression characteristics of multi-components pharmaceutical powders with different mass ratios was developed. The uniaxial flat-face compression tests of powder lactose, starch and microcrystalline cellulose were carried out, separately. Therefore, the Kawakita equation parameters of the powder materials were obtained. The uniaxial flat-face compression tests of the powder mixtures of lactose, starch, microcrystalline cellulose and sodium stearyl fumarate with five mass ratios were conducted, through which, the correlation between mixture density and loading pressure and the Kawakita equation curves were obtained. Finally, the theoretical prediction values were compared with experimental results. The analysis showed that the errors in predicting mixture densities were less than 5.0% and the errors of Kawakita vertical coordinate were within 4.6%, which indicated that the theoretical model could be used to predict the direct compaction characteristics of multi-component pharmaceutical powders.

Theoretical analysis and experimental research of pharmaceutical powder compression characteristics base on the Heckel equation / 中国药学杂志

OBJECTIVE: To built a general theoretical prediction model of pharmaceutical powder mixtures with different components and mass fraction base on powder compaction Heckel equation. METHODS: Uniaxial compression tests were conducted with four excipients, and the Heckel equation parameters were got. The uniaxial compression tests of mixtures with different mass fraction were conducted; the change laws of density and porosity with applied pressure and the Heckel equation curves were obtained. RESULTS: The comparison of theoretical prediction model and experimental results showed that the porosity error and the Heckel vertical coordinate error were less than 4% and the density error was less than 2.5%. CONCLUSION: The established model has universality to predict the compression characteristics of multicomponent powders of any proportion composition.